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Home > 師資類別>合聘教師>姚少凌
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姚少凌  教授
: (03)4638800 分機3553
: Yao@saturn.yzu.edu.tw
研究室 : 2409
實驗室 : 幹細胞與細胞工程實驗室

學歷
國立清華大學化學工程系博士2000.9 至 2004.6
經歷

財團法人 食品工業發展研究所研究員2004.10 至2009.07

財團法人 食品工業發展研究所 兼任副研究員2002.04 至 2004.06

研究專長
細胞工程
組織工程
生化工程
得獎或研究成果

 

代表作
(A)    期刊論文Articles (Since 2004)
 
1.Hung CJ, Yao CL, Cheng FC, Wu ML, Wang TH, Hwang SM., “Establishment of immortalized mesenchymal stem cells with red fluorescence protein expression for in vivo transplantation and tracing in the rat model with traumatic brain injury”, Cytotherpay. (Submitted)
 
2.Chen TW, Hwang SM, Chu IM, Hsu SC, Hsieh TB, Yao CL*, “Characterization and transplantation of induced megakaryocytes from hematopoietic stem cells for rapid platelet recovery by a two-step serum-free procedure”, Experimental Hematology 2009. (In press)
 
3.Chen TW, Yao CL, Chu IM, Chuang TL, Hsieh TB, Hwang SM., “Large Generation of Megakaryocytes from Serum-Free Expanded Human CD34+ Cells”, Biochemical and Biophysical Research Communications 2009;378:112-117.
 
4.Kao IT, Yao CL, Chang YJ, Hsieh TB, Hwang SM., “Chondrogenic Differentiation of Human Mesenchymal Stem Cells from Umbilical Cord Blood in Thermoreversible Gelation Polymer”, Chinese Journal of Physiology 2008;51:252-258.
 
5.Chang CL, Lin ME, Hsu HY, Yao CL, Hwang SM, Pan CY, Hsu CY, Lee H., “Lysophosphatidic acid-induced interleukin-1β expression is mediated through Gi/Rho and the generation of reactive oxygen species in macrophages”, Journal of Biomedical Science 2008;15:357-363.
 
6.Yeh HJ, Yao CL, Chen HI, Cheng HC, Hwang SM., “Cryopreservation of human limbal stem cells ex vivo expanded on amniotic membrane”, Cornea 2008; 27:327-333. (Troutman Prize, The Cornea Society 2008)
 
7.Yao CL, Hwang SM., “Ex Vivo Expansion of Hematopoietic Stem Cells from Human Cord Blood in Serum-Free Conditions”, Methods in Molecular Biology 2007;407:165-175.
 
8. Kao IT, Yao CL, Kong ZL, Wu ML, Chuang TL, Hwang SM., “Generation of Natural Killer Cells from Serum-free Expanded Human Umbilical Cord Blood CD34+Cells”, Stem Cells and Development 2007;16:1043-1052.
 
9.Yao CL, Feng YH, Lin XZ, Chu IM, Hsieh TB, Hwang SM., “Characterization of serum-free ex vivo-expanded hematopoietic stem cells derived from human umbilical cord blood CD133+ cells”, Stem Cells and Development 2006;15:70-80.
 
10. Yao CL, Hwang SM., “Systematic strategy approach in medium design”, Experimental Hematology 2005;33:1273-1274.
 
11. Yao CL, Chu IM, Hsieh TB, Hwang SM., “A systematic strategy to optimize ex vivo expansion medium for human hematopoietic stem cells derived from umbilical cord blood mononuclear cells”, Experimental Hematology 2004; 32: 720-727.
 
(B)    會議論文Conference Publications (Since 2004)
 
1.Yao CL, Chen TW, Chiou TJ, Chen PM, Hsu SC, Hwang SM., “Characterization and transplantation of serum-free ex vivo–expanded peripheral blood hematopoietic stem cells for recovery of bone marrow function”, 第十四屆生化工程研討會, 台中, 台灣, June 2009.
 
2.Chen TW, Hwang SM, Chu IM, Hsu SC, Yao CL*., “Characterization and transplantation of induced megakaryocytes from hematopoietic stem cells for rapid platelet recovery by a two-step serum-free procedure”, 第十四屆生化工程研討會, 台中, 台灣, June 2009. (The First Prize in Oral Presentation Award)
 
3.Chang YP, Kao IT, Hwang SM, Yao CL., “Generation of chondrocytes from serum-free expanded human mesenchymal stem cells”, 第十四屆生化工程研討會, 台中, 台灣, June 2009.
 
4.Chen TW, Yao CL, Chu IM, Hsu SC, Hwang SM., “Characterization and transplantation of serum-free induced megakaryocytes from hematopoietic stem cells into NOD/SCID mice for rapid platelet recovery”, International Symposium of Stem Cells and Bioengineering 2009, Tainan, Taiwan, May 2009. (The First Prize in Poster Award)
 
5.Yao CL, Chen TW, Chiou TJ, Chen PM, Hsu SC, Hwang SM., “Characterization and transplantation of serum-free ex vivo–expanded peripheral blood hematopoietic stem cells from hematological malignancy patients and healthy donors into irradiated NOD/SCID mice”, International Symposium of Stem Cells and Bioengineering 2009, Tainan, Taiwan, May 2009.
 
6.Yao CL, Chen TW, Hwang SM., “Mass production of megakaryocytes from human hematopoietic stem cells by two steps of serum-free conditions for rapid platelet recovery”, 15th annual meeting of International Society for Cellular Therapy (ISCT), San Diego, CA, USA, May 2009.
 
7.Yao CL, Chen TW, Chu IM, Hsu SC, Hwang SM., “Characterization and mass production of megakaryocytes induced from hematopoietic stem cells under serum-free condition”, 2nd Pan Pacific Symposium on Stem Cells Research 2009, Taichung, Taiwan, April 2009. (Award of Best Paper)
 
8.Yao CL, Chang YJ, Wu ML, Hwang SM., “Characterization of expanded mesenchymal stem cells in the serum-free medium”, International Symposia on Stem Cells, Epigenetics and Development, Taipei, Taiwan, Sep. 2008.
 
9. Chuang TL, Yao CL, Hwang SM., “Characterization of natural killer cells induced from serum-free expanded umbilical cord blood CD34+ cells”, 第十三屆生化工程研討會, 桃園, 台灣, June 2008.
 
10.Chen TW, Yao CL, Chu IM, Chuang TL, Hwang SM., “Generation and Characterization of Megakaryocytes from Serum-Free Expanded Human Umbilical Cord Blood CD34+ Cells”, 第十三屆生化工程研討會, 桃園, 台灣, June 2008.
 
11. Yao CL, Chang YJ, Wu ML, Hwang SM., “Development of a serum-free medium for human mesenchymal stem cells”, 第十三屆生化工程研討會, 桃園, 台灣, June 2008.
 
12.Yao CL, Chang YJ, Wu ML, Hsu LF, Hwang SM., “Development of a serum-free medium for human mesenchymal stem cells”, 6th International Society of Stem Cell Research Annual Meeting, Philadelphia, PA, USA, June. 2008.
 
13.Hung CJ, Wu ML, Hsu LW, Yao CL, Hwang SM., “Establishment of two immortalized mesenchymal stem cell lines by exogenous expression of telomerase reverse transcriptase”, 6th International Society of Stem Cell Research Annual Meeting, Philadelphia, PA, USA, June. 2008.
 
14.Yao CL., ”Serum-Free Expansion and Differentiation of Hematopoietic Stem Cells”, 1st Pan Pacific Symposium on Stem Cells Research 2008, Taichung, Taiwan, June 2008. (Invited Speaker)
 
15.Yao CL., ”造血幹細胞無血清培養增生之研究”, 中華民國基因檢測技術暨幹細胞研究發展協會暨國泰綜合醫院三十週年院慶聯合研討會-間質幹細胞與再生醫學運用之展望研討會, 台北, 台灣, March 2008. (Invited Speaker)
 
16.Lo JM, Yen CL, Lo ST, Yao CL, Lee TW., “99mTc-tricarbonyl labeled trastuzumab as an imaging agent for breast cancer with HER2 overexpression’, Eur. J. Nucl. Med. Mol. Imaging. 2007;34:S259.
 
17. Chiou TJ, Yao CL, Hwang SM, Chen PM., “Serum-free ex vivo–expanded peripheral blood hematopoietic stem cells derived from hematological malignancy patients and healthy donors”, The 11th Congress of the International Society of Hematology, Asian-Pacific Division and 12th Congress of Asian-Pacific Bone Marrow Transplantation, Beijing, China, Sep. 2007.
 
18.Yao CL, Kao IT, Chen TW, Wu ML, Chuang TL, Chu IM, Hwang SM., “Applications of serum-free expanded hematopoietic stem cells and their generated cells”, 第十二屆生化工程研討會, 桃園, 台灣, June 2007.
 
19.Chen TW, Yao CL, Chu IM, Hwang SM., “Serum-free induction of megakaryocytes derived from serum-free expanded hematopoietic stem cells“, 第十二屆生化工程研討會, 桃園, 台灣, June 2007. (第十二屆生化工程研討會壁報論文競賽優勝獎)
 
20.Kao IT, Wu ML, Yao CL, Hwang SM., “Generation of natural killer cells from serum-free expanded human umbilical cord blood CD34+ cells”, 5th International Society of Stem Cell Research Annual Meeting, Cairns, Queensland, Australia, June. 2007.
 
21.Chang CL, Perng YC, Yao CL, Hwang SM, Lee H., “Lysophosphatidic acid induces IL-1 expression and reactive oxygen species production in human macrophages”, 2007 Experimental Biology Annual Meeting, Washington, DC, USA, April 2007.
 
22.Yao CL, Kao IT, Wu ML, Chuang TL, Hwang SM., “Serum-Free Induction of Natural Killer Cells Derived from Serum-Free Expanded Hematopoietic Stem Cells”, 2007 Annual Meeting of Taiwan Society for Stem Cell Research, Taichung, Taiwan, April 2007.
 
23.Chen TW, Yao CL, Chu IM, Hwang SM., “Development of Ex Vivo Serum-Free Inducyion System for Megakaryocytes.” 2007 Annual Meeting of Taiwan Society for Stem Cell Research, Taichung, Taiwan, April 2007.
 
24.Yao CL, Kao IT, Chiou TJ, Chen PM, Hwang SM., “Serum-free ex vivo–expanded fresh and cryopreserved hematopoietic stem cells derived from hematological malignancy patients and healthy donors”, 2006 International Symposium on Stem Cells and Regenerative Medicine, Taipei, Taiwan, Oct. 2006.
 
25.Chen TW, Yao CL, Chu IM, Hwang SM., “Medium Optimization for Ex Vivo Expansion of Megakaryocytes from Serum-Free Expanded Hematopoietic Stem Cells”, International Symposium on Recent Advances in Stem Cell Research and 2006 Annual Meeting of Taiwan Society for Stem Cell Research, Taipei, Taiwan, Sep. 2006.
 
26.Kao IT, Wu ML, Yao CL, Hwang SM., “Generation of natural killers cells derived from serum-free expanded hematopoietic stem cells and cytokine screening for natural killer cell induction by a systematic method”, International Symposium on Recent Advances in Stem Cell Research and 2006 Annual Meeting of Taiwan Society for Stem Cell Research, Taipei, Taiwan, Sep. 2006.
 
27.Yao CL, Kao IT, Chiou TJ, Chen PM, Hwang SM., “Compare the characterization of serum-free ex vivo–expanded peripheral blood hematopoietic stem cells derived from patients with hematological malignancies and healthy donors”, 第十一屆生化工程研討會, 新竹, 台灣, June 2006.
 
28.Kao IT, Wu ML, Yao CL, Hwang SM., “Ex vivo expansion and induction of natural killer cells derived from serum-free expanded hematopoietic stem cells by systematic strategy”, 第十一屆生化工程研討會, 新竹, 台灣, June 2006.
 
29.Chen TW, Yao CL, Chu IM, Hwang SM., “Optimize cytokine cocktails for induction of megakaryocytes from serum-free expanded hematopoietic stem cells by factorial designs”, 第十一屆生化工程研討會, 新竹, 台灣, June 2006.
 
30.Yao CL, Kao IT, Chiou TJ, Chen PM, Hwang SM., “Serum-free ex vivo expansion of peripheral blood hematopoietic stem cells derived from patients with hematological malignancies”, 12th annual meeting of International Society for Cellular Therapy (ISCT), Berlin, Germany, May 2006. Cytotherapy 2006;8:poster no.105 (Supplement 1).
 
31.Yao CL, Kao IT, Wu ML, Hwang SM., “A large-scale and closed culture system for the ex vivo expansion of human hematopoietic stem cells”, 九十四年度生醫材料暨藥物制放研討會, 新竹, 台灣, Nov. 2005.
 
32. Kao IT, Chang YJ, Yao CL, Hwang SM., “Chondrogenesis of human umbilical cord blood-derived mesenchymal stem cell embedded in Mebiol Gel”, 九十四年度生醫材料暨藥物制放研討會, 新竹, 台灣, Nov. 2005.
 
33.Yao CL, Feng YH, Lin XZ, Chu IM, Hwang SM., “Functional analysis of ex vivo expanded cells derived from human umbilical cord blood CD133+ cells”, 第十屆生化工程研討會, 台北, 台灣, June 2005. (第十屆生化工程研討會壁報論文競賽特優獎)
 
34.Kao IT, Kong ZL, Wu ML, Yao CL, Hwang SM., “Induction of natural killer cells from ex vivo expanded human cord blood CD34+ cells”, 第十屆生化工程研討會, 台北, 台灣, June 2005.
 
35.Yao CL, Chu IM, Hsieh TB, Hwang SM., “Telomerase activity in hematopoietic stem cells cultured in serum-free medium”, The 7th Asia-Pacific Biochemical Engineering Conference, Jeju Island, Korea, May 2005.
 
36.Kao IT, Kong ZL, Wu ML, Hsu LW, Yao CL, Hwang SM., “Generation of natural killer cells from serum-free expanded CD34+ cells isolated from human umbilical cord blood”, The 17th Annual and International Meeting of the Japanese Association for Animal Cell Technology, Nagoya, Japan, Nov. 2004.
 
(C)其他著作(含專利、出書…等)Others(Since 2004)

C1
雜誌文章 Article in Magazine:
 
1.Lo JM, Yen CL, Lo ST, Yao CL, Lee TW., “99mTc-tricarbonyl labeled trastuzumab as an imaging agent for breast cancer with HER2 overexpression”, Eur. J. Nucl. Med. Mol. Imaging. 2007;34:S259.
 
2.姚少凌, 黃效民., “活躍的造血幹細胞”, 科學發展月刊, 2007;414:12-17.
 
3. Yao CL, Kao IT, Chiou TJ, Chen PM, Hwang SM., “Serum-free ex vivo expansion of peripheral blood hematopoietic stem cells derived from patients with hematological malignancies”, Cytotherapy 2006;8:S105.
 
4. Kao IT, Kong ZL, Wu ML, Hsu LW, Yao CL, Hwang SM., “Generation of Natural Killer Cells from Serum-Free Expanded CD34+ Cells Isolated from Human Umbilical Cord Blood”, In: Animal Cell Technology: Basic & Applied Aspects (ISBN: 978-1-4020-4312-3). Iijima S and Nishijima KI, ed. Springer: Netherlands. 2006, pp 211–218.

C2
專利Patent:

1.
“Whole processes in the serum-free condition for large generation of megakaryocytes from human CD133+ cells.” (Under review)
 
2.“Stroma-free, ferum-free, and chemically defined medium and method for ex vivo hematopoietic stem cells expansion using the same.” (US 2007/0207544A1, US Patent, Under review)
 
3. “Stroma-free, ferum-free, and chemically defined medium and method for ex vivo hematopoietic stem cells expansion using the same.” (US 2006/0024827 A1; 94125613, Under review)
 
4.“Optimizing culture medium for CD34 hematopoietic cell expansion.” (US 2005/0032122A1, US Patent, Under review)

 

 
(D) 近五年計畫 Project List (Since 2004)
 
學年度 擔任工作 計劃編號 計劃名稱 委託單位
98 主持人 NSC98-2221-E-155-072- 癌症免疫疫苗的開發:從人類造血幹細胞進行樹突狀細胞體外無血清增殖誘導技術之研發 NSC,國科會

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